Strains in the interosseous membrane do different things in the upper versus the lower extremity due to the predominant direction the fibers of the interosseous membrane run. In the upper extremity, when the radius and ulna move in relationship to one another, the radius typically moves distally. This movement in the interosseous membrane approximates the radius and ulna which crowds the bones of the wrist. In this crowding, the lunate moves anteriorly (anatomic position), gets closer to the median nerve and predisposes the patient to carpal tunnel syndrome. Correction involves returning the radius and ulna to their proper anatomic position, which will spread the interosseous membrane.
The lower extremity interosseous membrane has fibers running in the opposite direction. When the fibula drops distally it spreads the tibia and fibula apart. This allows rotational motion of the talus between the bones that make up the mortise (giving you a non-fracture ankle sprain). As long as the fibula stays in that distal position, the patient is predisposed to repeat ankle sprains. Correction involves returning the tibia and fibula to their correct position which approximates and stabilizes the talus between the tibia and fibula.